Covid19
Conditions
Keywords
sex, gender, thrombosis, immunity, gut microbiota
Brief summary
Sex and gender matter to health equity, especially in a pandemic. Sex (a biological attribute) and gender (a social construct) may influence an individual's susceptibility, vulnerability and exposure to infectious disease. In previous coronavirus epidemics (SARS and MERS), male sex was associated with worse outcomes. Both immune and the hemostatic response display ample sexual dimorphism. The primary aim of the study is to determine whether sex differences in biomarkers of platelet and immune function, gut microbiome, clinical characteristics, therapy, clinical cost sensitive outcomes (i.e. in-hospital transition of care, case severity, and mortality due to COVID-19) exist in patients affected by COVID-19.
Interventions
None listed
Sponsors
University of Roma La Sapienza
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with laboratory confirmed SARS-Cov-2 infection of any severity.
Exclusion criteria
* Pregnancy. * Younger than 18 years of age.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sex differences in platelet and immune function and COVID19 severity | 3 months | Sex differences in biomarkers of platelet and immune function correlate with severity of disease |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiome and COVID19 severity | 3 months | Differences in the gut microbiome correlate with severity of disease |
Countries
Italy
Contacts
Primary ContactStefania Basili, MD
Outcome results
None listed