Spontaneous Coronary Artery Dissection
Conditions
Keywords
spontaneous coronary artery dissection (SCAD), myocardial infarction, sudden cardiac arrest, acute coronary syndrome
Brief summary
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.
Detailed description
Spontaneous Coronary Artery Dissection (SCAD) is an under-diagnosed cause of acute coronary syndrome (ACS), myocardial infarction (MI) and sudden cardiac arrest. The inner lining of the coronary artery splits and allows blood to seep into the adjacent layer, forming a blockage (hematoma), or the artery continues to tear, creating a flap of tissue that blocks blood flow in the artery. SCAD strikes generally healthy, younger individuals (average age 42) who do not have traditional cardiac risk factors. Warning signs of SCAD encompass the full range of ACS and MI symptoms, from vague to classic. The cause of SCAD is currently unknown and the psychosocial impact of SCAD is traumatizing. The work of the iSCAD Registry will encompass the physical and psychosocial study of SCAD.
Interventions
None listed
Sponsors
SCAD Alliance
PERFUSE Study Group
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either: 1. Inpatient wards of the enrolling medical centers during the acute presentation of SCAD, or 2. Outpatient cardiovascular clinics of enrolling medical centers. Participants must be: * 18 years of age or older * Diagnosis of SCAD or history of SCAD based on coronary angiography, either catheter-based or coronary CTA * Suspected SCAD by coronary angiography
Exclusion criteria
1. Coronary dissection in association with atherosclerosis or as a result of iatrogenic injury 2. Inability to provide informed consent 3. Inability to complete study-related patient questionnaires 4. Inability to understand and complete patient questionnaires independently
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Descriptive Data | Continuous time frame following index event for an average of 3 years from study contact date | Participant demographic, historical, clinical characteristics, and treatment data |
| Clinical Outcomes | Continuous time frame following index event for an average of 3 years from study contact date | Prospectively collected long-term outcomes including recurrent myocardial infarction, hospitalization, heart failure, stroke or transient ischemic attack, arrhythmia, and all cause mortality |
| Psychosocial Outcomes | Continuous time frame following index event for an average of 3 years from study contact date | Prospectively collected data on participant's mental health using validated questionnaires |
Countries
Australia, United States
Contacts
STUDY_CHAIREsther Kim, MD
Chair, Steering Committee
PRINCIPAL_INVESTIGATORMalissa Wood, MD
Member, Steering Committee
PRINCIPAL_INVESTIGATORSahar Naderi, MD
Member, Steering Committee
Outcome results
None listed