Periodontitis
Conditions
Keywords
gingival crevicular fluid, resolvin D1
Brief summary
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels. A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.
Interventions
PROCEDUREperiodontal therapy
Non surgical periodontal therapy was performed to patients with peridontitis
Sponsors
Ordu University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Stage 3, Grade B and generalized periodontitis patients
Exclusion criteria
* excessive forces; * presence of systemic diseases * administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months * having received non-surgical periodontal treatment within the past 6 months * allergy or sensitivity to any drug, * pregnancy, lactation * current and former use of tobacco.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biochemical parameter (resolvin D1) | Baseline and 1 month after NSPT | The changes in levels of resolvin D1 after periodontal treatment determined by ELISA. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Probing pocket depth | Baseline and 1 month after NSPT | The changes in probing pocket depth after periodontal treatment were evaluated |
| Clinical attachment level (CAL) | Baseline and 1 month after NSPT | The changes in CAL after periodontal treatment were evaluated |
| Plaque index (PI) | Baseline and 1 month after NSPT | The changes in PI after periodontal treatment were evaluated |
| Gingival index (GI) | Baseline and 1 month after NSPT | The changes in GI after periodontal treatment were evaluated |
Countries
Turkey (Türkiye)
Outcome results
None listed