Non-invasive Substrate Evaluation in Atrial Fibrillation

Non-invasive Substrate Evaluation in Atrial Fibrillation Using Cardiac Magnetic Resonance and Electrocardiographic Imaging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04496336

Acronym

NOISE-AF

Enrollment

Registered

2020-08-03

Start date

2020-02-20

Completion date

2022-11-20

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C14.280.067.198

Keywords

Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation

Brief summary

The study aims to assess the right and left atrial electrophysiological substrate in atrial fibrillation patients using the invasive electroanatomic map (basal and with extraestimulus) as well as its correlation with cardiac magnetic resonance and electrocardiographic imaging. The results will also be compared when the patient is in sinus rhythm and atrial fibrillation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Atrial fibrillation paroxysmal or persistent with criteria for percutaneous ablation

Exclusion criteria

* Cardiomiopathy (FEVI\<40%) or significant valvulopathy. * MRI not possible or contraindicated. * Previous atrial fibrillation ablation.

Design outcomes

Primary

Measure	Time frame	Description
Correlation between conduction velocity and MRI fibrosis.	Baseline	The conduction velocity in sinusal rhythm and with extra estimuli will be correlated with the MRI late gadolinium enhancement sequence (MRI-LGE).

Secondary

Measure	Time frame	Description
Correlation between voltage and MRI fibrosis.	Baseline	The voltage in sinus rhythm and in atrial fibrillation will be correlated with the MRI-LGE.
Correlation between electrocardiographic image (ECGi) and MRI-LGE.	Baseline	The xxx of the ECGi will be correlated with the MRI-LGE.

Countries

Spain

Outcome results