Addition of Neostigmine to Levobupivacaine

The Effect of Addition of Neostigmine to Levobupivacaine in Male Patients Receiving Ultrasound Guided Spermatic Cord Block for Postoperative Analgesia in Testicular Sperm Extraction Surgery:

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04492319

Enrollment

112

Registered

2020-07-30

Start date

2020-09-29

Completion date

2023-12-20

Last updated

2024-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spermatic Cord Block

Keywords

Spermatic Cord Block, Neostigmine, Levobupivacaine

Brief summary

Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as neostigmine.

Interventions

DRUGControl Test

spermatic cord block by 19 ml Levobupivacaine 0.5% plus 1 ml 0.9 normal saline in each side

DRUGNeostigmine

spermatic cord block by 19 ml Levobupivacaine 0.5% plus 1 ml neostigmine 500 μg in each side .

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

MALE

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients aged from 20 to 45 years. * American Society of Anesthesiologists I-II. * Undergoing Testicular Sperm Extraction Surgery. * BMI from 18.5 to 40 kg/m2

Exclusion criteria

* Patient refusal * Contraindications to regional anesthesia (bleeding disorders e.g. international normalized ratio \>1.5, Prothrombin Concentration \<70%, platelet count\<100 × 109, use of any anti-coagulants, local infection, etc.). * Known allergy to local anesthetics. * ASA III-IV. * Patients aged less than 18 or more than 60. * Body mass index \>35.:

Design outcomes

Primary

Measure	Time frame	Description
Time from end of surgery to the first postoperative analgesic request	UP TO 24 HOURE	(duration of the block).

Secondary

Measure	Time frame	Description
visual analog scale	UP TO 24 HOURE	visual analog scale ; 0 is bad / 10: is good
spermatic cord block time	UP TO 1 HOURE	The mean time needed to perform spermatic cord block
Incidence of complications	up to 24 hours	complications
Postoperative analgesic use	up to 24 hours	amount of Acetaminophen used postoperative

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026