Liver Metastasis Colon Cancer
Conditions
Keywords
Liver metastasis Colon Cancer, Circulating Tumour DNA, Selective Internal Radiation Therapy
Brief summary
Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.
Detailed description
In this study, the investigators seek to investigate biological aspects in patients with colorectal cancer liver metastasis undergoing treatment with Selective Internal Radiation Therapy, by translational analysis of biological samples. SIRT will be conducted as per standard procedure at Aarhus University Hospital. Translational blood samples will be drawn pre-treatment and during follow up. The total cell free DNA level will be quantified in all samples. The samples will be analysed for tumour specific mutations such as the KRAS, BRAF and NRAS oncogenes. The investigators expect to include up to 30 patients. This is a purely observational translational study. Results will be analysed in relation to outcome data. The study is conducted in collaboration with: Department of Gastroenterology and Hepatology, Aarhus University Hospital Department of Radiology, Aarhus University Hospital Department of Nuclear Medicine, Aarhus University Hospital
Interventions
None listed
Sponsors
Aarhus University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease * Diagnosis of liver metastasis may be made by histo- or cyto-pathology, or by clinical and imaging criteria. * The Liver metastasis are not eligible for resection, RFA or SBRT * All patients must be off all chemotherapeutic regimens for 14 days prior to SIRT treatment * All patients must be off vascular endothelial growth factor inhibitors for 6 weeks prior to SIRT treatment * Progressive disease, severe intolerance during or following all standard lines of chemo-therapy * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 * Age 18 years or older * Able to understand written information * Consent to samples for translational research
Exclusion criteria
* Pretherapeutic work-up procedure with Tc-99m macroaggregated albumin (MAA) scintigraphy showing extrahepatic foci in GI-tract * Evidence of any detectable Tc-99m macroaggregated albumin deposition in the stomach or duodenum, after application of established angiographic techniques to stop such deposition * Previous radiation therapy to the lungs and/or to the upper abdomen overlapping with dose to the liver at interventionist´s decision * Lung shunt greater than 20% or \> 30 Gray radiation absorbed dose to the lungs, at estimated by Tc-99m-MAA * Pregnancy * Symptomatic lung disease precluding SIRT at interventionist´s decision * Active uncontrolled infection * Any pre-treatment laboratory findings within 30 days of treatment demonstrating: alanine aminotransferase level greater than 5 times upper normal limit and/or serum bilirubin greater than 2 mg/dl (\>34 umol/l) * Current or previously evidence of ascites on CT-scan or physical examination * Tumour volume greater than 50% of liver volume * Conditions precluding translational samples
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility and translational analysis | When 5 patients are included, the blood samples will be analysed for explorative analysis (expected after the first year). In all we expect to include 30 patients if positive results. | Investigating potential prognostic and predictive markers for efficacy by molecular characteristics and mutational analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Response Rate | 6 months | According to RECIST 1.1 |
| Progression Free Survival | 3 years | — |
| Overall Survival | 3 years | — |
Countries
Denmark
Contacts
Primary ContactLouise B Callesen, MD
Outcome results
None listed