Colorectal Cancer
Conditions
Keywords
colorectal cancer, cognitive impairment, chemotherapy, dual-task walking, surgery
Brief summary
The aims of this three-year study are to explore cognitive function under different stages of colorectal cancer (CRC) and its related factors; and understand its disturbance and coping process caused by cancer-induced cognitive impairment (CICI) from patient perspective; and further to test effect of dual-task walking on improving cognitive function in CRC patients.
Detailed description
In the first phase, a cross-sectional design will be used to explore both subjective and objective cognitive functions under different cancer treatment trajectories of CRC and their related factors. Additionally, a risk prediction model for mild cognitive impairment will be developed by examining the effects of surgery and chemotherapy on cancer-induced cognitive impairment (CICI) , with the aim of identifying high-risk populations. A qualitative design will be employed to understand the disturbances and coping processes caused by CICI from the patient's perspective. A longitudinal design will be used to examine the effects of surgery and chemotherapy on cognitive function. In the second phase, we will develop a dual-task walking training program and use a randomized controlled trial to test its effect on improving cognitive function (memory, executive function, and attention) in CRC patients.
Interventions
BEHAVIORALdual-task walking
Participants in the experimental group will receive 3 times interventions during chemotherapy and 12 weekly phone calls or via LINE to assess barriers of dual-task walking.
Sponsors
National Taiwan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with newly diagnosed stage I to III colorectal cancer.
Exclusion criteria
* Patients with cancer other than colorectal cancer or have cancer recurrence.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Self-report Questionnaire | In the cross-sectional design, data will be collected at a one-time point; in the longitudinal design and the randomized controlled trial, data will be collected at baseline and 3, 6, and 12 months follow-up. | The questionnaires include (1) 37 items to assess perceived cognitive functioning and (2) 6 items to assess perceived cognitive impairment. |
| Neuropsychological test battery | In the cross-sectional design, data will be collected at a one-time point; in the longitudinal design and the randomized controlled trial, data will be collected at baseline and 3, 6, and 12 months follow-up. | A battery of neuropsychological tests will be used to assess cognitive domains of executive function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self-report Questionnaire | In the cross-sectional design, data will be collected at a one-time point; in the longitudinal design and the randomized controlled trial, data will be collected at baseline and 3, 6, and 12 months follow-up. | The questionnaire includes 24 items to assess symptom severity |
Other
| Measure | Time frame | Description |
|---|---|---|
| Self-report Questionnaire | In the cross-sectional design, data will be collected at a one-time point; in the longitudinal design and the randomized controlled trial, data will be collected at baseline and 3, 6, and 12 months follow-up. | The questionnaire includes 15 items to assess fatigue level |
Countries
Taiwan
Contacts
Primary ContactShiow-Ching Shun, PHD
Backup ContactShiow-Ching Shun, PHD
Outcome results
None listed