Primary Ciliary Dyskinesia
Conditions
Keywords
Nitric oxide, Intranasal nitric oxide, Beet juice
Brief summary
The purpose of this study is to determine the effect of a dietary supplement rich in nitric oxide (NO) on nasal nitric oxide and fractional exhaled nitric oxide (FeNO),on ciliary beat frequency assessed by high-speed digital video microscopy and on lung function assessed by spirometry in normal patients and patients with Primary ciliary dyskinesia (PCD).
Interventions
DIETARY_SUPPLEMENTBeet-it Juice
Patients will ingest 1 bottle (70ml) of beet-it juice (98% concentrated beet juice, 2% lemon juice containing 400 mg/6.5 mmol nitrate).
Sponsors
The University of Texas Health Science Center, Houston
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
4 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
Experimental group: * PCD patients Control Group: * patients with no known chronic lung disease * 18 years to 99 years
Exclusion criteria
(both PCD patients and control group): * any other pulmonary co-morbidities and diseases entities like cystic fibrosis, nasal sinus surgery, nasal sinus hypoplasia/aplasia, deviated nasal septum, nasal polyps and with upper respiratory tract infection * patients allergic to beet * a known prolonged bleeding disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in nasal NO as measured by a chemiluminescence analyzer | Baseline,after beet juice consumption(1 hour after consumption) |
| Change in nasal FeNO as measured by using the NIOX MINO® Airway Inflammation Monitor | Baseline,after beet juice consumption(1 hour after consumption) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in ciliary beat frequency as measured using high-speed video-microscopy (HSVM) | after beet juice consumption(2 hours after consumption) | — |
| Change in lung function as measured by spirometry | Baseline,after beet juice consumption(2 hours after consumption) | spirometry is used to assess how well your lungs work by measuring how much air you inhale,how much you exhale and how quickly you exhale |
Countries
United States
Contacts
Primary ContactRicardo A Mosquera, MD
Backup ContactDiana Castillo
Outcome results
None listed