PND
Conditions
Keywords
PND,anesthesia method, elderly
Brief summary
Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery. Different anesthesia methods have different incidences of PND, but it's still unknow which is better between spinal anesthesia and nerve block combined with general anesthesia. We will apply a psychometric battery test which contain different cognitive domains to estimate the incidence of PND at a week a month and a year after surgery with different anesthesia methods. Study has showed that functional magnetic resonance imaging (fMRI) could detect a cognitive decline through spontaneous neuronal activity in the cortex and hippocampus. In our study, multi-mode imaging technology is used to conduct in-depth research on MRI and make correlation analysis with cognitive function.
Interventions
DEVICEnerve block combined with general anesthesia
Patients in this group receive nerve block combined with general anesthesia.
DEVICEspinal anesthesia
Patients in this group receive spinal anesthesia.
Sponsors
Shenzhen Second People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 60-85years * ASA I-III * Received elective surgery of unilateral lower extremity orthopedics * The anesthesia lasted more than 2 hours
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PND seven days after surgery | seven days after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of PND one year after surgery | one year after surgery |
| Hospital stay | one to two weeks after surgery |
| Number of patients entrance the ward of ICU after surgery | one week post-operation |
| Mortality rate | one year after surgery |
| Postoperative complications | one month post-operation |
| Incidence of PND one month after surgery | one month after surgery |
| ADL of frontal lobe | one day pre-operation, one week post-operation |
| BOLD of the whole brain | one day pre-operation, one week post-operation |
| ADL of temporal lobe | one day pre-operation, one week post-operation |
| ADL of occipital lobe | one day pre-operation, one week post-operation |
| One year event-free survival | one year after surgery |
| ADL of frontal lobe，temporal lobe and occipital lobe | one day pre-operation, one week post-operation |
Countries
China
Contacts
Primary ContactZhiheng Liu, MD
Backup ContactNanbo Luo, MD
Outcome results
None listed