Atherosclerosis
Conditions
Keywords
Coffee, BMI, Leptin, Folic acid, Vitamin B12
Brief summary
The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12
Detailed description
Coffee consumption has been associated with several risk factors leading to cardiovascular diseases (CVDs), including hyperhomocysteinemia and hyperlipidemia. Frequent coffee consumption has beneficial effects in reducing the risk of diabetes mellitus (DM) type 2, obesity, liver disease, CVDs, some types of cancer, Parkinson's disease, and Alzheimer's disease. Controversies concerning coffee consumption benefits and risks in regards for CVDs were mentioned in many studies. Folic acid and vitamin B12 are necessary vitamins in homocysteine metabolism which is a risk factor for atherosclerosis. Leptin, is a hormone linked to obesity and it could be related to atherosclerosis. The combined effect of coffee consumption and body weight on the levels of leptin, folic aid, and vitamin B12 is not well studied. In our study, we will study the effect of coffee consumption in males with different body mass indices to see the effect of several important parameters such as leptin, Folic acid, and vitamin B12.
Interventions
BEHAVIORALNormal BMI and moderate coffee consumption
Normal BMI and moderate coffee consumption
BEHAVIORALNormal BMI and heavy coffee consumption
Normal BMI and heavy coffee consumption
BEHAVIORALoverweight and moderate coffee consumption
overweight and moderate coffee consumption
BEHAVIORALoverweight and heavy coffee consumption
overweight and heavy coffee consumption
Sponsors
Applied Science Private University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
18 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
* male, * ASU student, * do not have any acute or chronic medical conditions.
Exclusion criteria
* students who used any medications for either an acute and/or a chronic condition during the past 3 months prior to the study entry.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| leptin | Baseline | Plasma Concentration of leptin in ng /ml |
| folic acid | Baseline | Plasma Concentration of folic acid in ng /ml |
| Vitamin B12 | Baseline | Plasma Concentration of Vitamin B12 in pg /ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fasting blood glucose | Baseline | Plasma Concentration of glucose mg/dL |
| lipid profile | Baseline | Plasma Concentration of LDL, HDL in mg/dl |
Countries
Jordan
Outcome results
None listed