Lung Ultrasound in COVID-19 Patients

Early Lung Ultrasound Score Predicts Duration of Ventilation and ICU Mortality in COVID-19 Invasively Ventilated Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04487769

Acronym

LUS-COVID

Enrollment

137

Registered

2020-07-27

Start date

2020-06-01

Completion date

2020-12-31

Last updated

2024-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, Covid19, Ultrasound

Keywords

new coronavirus disease, coronavirus disease 2019, lung imaging, lung ultrasound, lung ultrasound score, prognostication, duration of ventilation, mortality

Brief summary

To assess the prognostic performance of an early global LUS score with respect to the mortality in ICU and duration of ventilation.

Detailed description

This is an international multicenter cohort study on data collected between March and April 2020. The first available lung ultrasound examination that used a 12-regions approach was used to calculate the global LUS score. Patients are included if they fulfilled the following criteria: 1) admitted to one of the participating ICU; 2) for invasive ventilation; 3) for respiratory failure due to confirmed COVID-19; and 4) having had a LUS examination performed within the first week of start of invasive ventilation. The primary and secondary outcomes were liberation from invasive ventilation and mortality. Demographic, clinical and outcome variables will be presented as percentages for categorical variables and as medians with interquartile ranges (IQR) for continuous variables. Receiver operating characteristics (ROC) analysis will be used to derive the prognostic discriminatory performance of global LUS score in determining succesful extubation and mortality at day 28. The Youden index will be used to derive the optimal cut-off. The association of global LUS with unfavourable outcomes are analyzed with Cox proportional hazard analysis (for successful extubation and alive at day 28), logistic regression models (mortality at day 28). Hazard ratio or odds ratio with 95% confidence intervals were calculated for each outcome.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Admitted to an ICU participating in this study between February 1, 2020 and April 30, 2020 * Confirmed with reverse transcriptase polymerase chain reaction (RT-PCR) COVID-19 infection * Having had received invasive ventilation * Having had examined at least once with lung ultrasound under invasive ventilation

Exclusion criteria

* Age \<18 years * First examination with LUS in patients already under extracorporeal membrane oxygenation (ECMO) support.

Design outcomes

Primary

Measure	Time frame	Description
Liberation from invasive ventilation	28 days	Patient who survived but remained invasively ventilated up to day 28 were marked without event. Patients who survived but were extubated were marked with an event at the day of successful extubation.

Secondary

Measure	Time frame	Description
Mortality	28 days	Patient who survived up to day 28 were marked without event. Patients who survived but were extubated were marked with an event at the day of successful extubation.

Countries

Netherlands

Outcome results