Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04486248

Enrollment

Registered

2020-07-24

Start date

2019-10-09

Completion date

2022-12-31

Last updated

2023-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals. On the one hand, the te-ASL sequence will be compared against a 3D pCASL with a PLD of 1800 ms, as the current reference according the Consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. On the other, as the implemented te-ASL sequence will have a 2D readout, it will also be compared to a 2D pCASL ASL sequence with the same PLD, in order to be able to disentangle differences due to the dynamic PLD scheme from those arising from the different read-out schemes.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* To sign the study informed consent form approved by the corresponding authorities. * Healthy men and women (older than 18 years old).

Exclusion criteria

* Inability or unwillingness to give written informed consent or communicate with the study staff or illiteracy. * Any contraindication to perform brain MRI procedure (e.g. pacemaker, MRI-incompatible aneurysm clips).

Design outcomes

Primary

Measure	Time frame	Description
ASL perfusion MRI data	Through study completion, an average of 1 year	Quantification of cerebral blood flow

Countries

Spain

Outcome results