Multiple Sclerosis
Conditions
Keywords
neuromodulation, spinal cord stimulation, walking function, spasticity
Brief summary
Epidural spinal cord stimulation (SCS) is currently regarded as one of the most promising intervention methods to improve motor function in individuals with severe spinal cord injury. In parallel, an increasing number of studies is suggesting that noninvasive SCS can improve spasticity and residual motor control in the same subject population. The present study explores whether single sessions of noninvasive SCS would improve walking performance and ameliorate spasticity in individuals with multiple sclerosis.
Interventions
DEVICEtranscutaneous spinal cord stimulation
electrical stimulation of the lumbosacral spinal cord through surface electrodes
Sponsors
Neurological Center, Otto Wagner Hospital
Medical University of Vienna
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* confirmed diagnosis of relapsing-remitting, primary- or secondary-progressive MS * lower-limb spasticity
Exclusion criteria
* acute relapse of MS * other neuromuscular diseases * active and passive implants at vertebral level T9 or caudally * dermatological issues at stimulation site * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Ashworth Scale | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| 10-m walk test | 24 hours |
| 2-min walk test | 24 hours |
| Timed up an go test | 24 hours |
Countries
Austria
Outcome results
None listed