Infertility, Female, Poor Response to Ovulation Induction
Conditions
Keywords
Poor responders, Embryo transfer, Cancellation rate, Implantation rate, Live birth rate
Brief summary
A Prospective cohort study including couples with poor responder females who undergoing ICSI
Detailed description
Purpose: To determine the optimal embryonic stage for transfer in poor responders. Method: Patients were divided into day 3 transfer group and day 5 transfer group. All cases had the same stimulation protocol and planning to do fresh embryo transfer. Assessments will be at Day 1, Day 3 and Day 5/6 according to Gardner's criteria 1999. Embryological and clinical data were recorded and then analyzed using SPSS (version 23) statistical software.
Interventions
OTHERCleavage stage transfer
transferring embryos through ICSI procedures for poor responders on cleavage stage of embryonic development.
OTHERBlast stage transfer
transferring embryos through ICSI procedures for poor responders on blast stage of embryonic development.
Sponsors
Ganin Fertility Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* poor responders females with AMH≤ 1.2ng and have ≤ 5 mature oocytes * couples whose planning to do fresh transfer * male partners have normal semen parameters according to WHO 2010.
Exclusion criteria
* sperm or oocyte donation * gestational carriers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth rate | delivery of healthy neonate after 37 weeks of pregnancy | percentage of cycles started with the intent of egg retrieval that led to a live birth. |
| Implantation rate | 6 weeks of pregnancy | Percentage of the implanted embryos number for each group / number of transferred embryos. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | 16:19 hours after intracytoplasmic injection(ICSI) | Percentage of fertilized oocyte (appearance of two pronuclei) / Number of injected oocytes |
| Cleavage rate | 72 hours after ICSI | Percentage of cleaved embryos / Number of fertilized oocytes |
| Clinical pregnancy rate | after 6 weeks of embryonic transfer | Percentage of pregnant cases with fetal heart / transferred cases for each group |
| Blast rate | 5:6 days of ICSI | Percentage of total blastocysts / Total cleaved embryos |
| High quality blast rate | 5:6 days of ICSI | Morphological grading of trophectoderm and Inner cell mass using Gardner's criteria 1999, from grade A and B ( A is the highest quality). Total high grade embryos/ total blast embryos. |
| High quality day 3 embryos | 72 hours after ICSI | High quality D3 embryos according to Gardner's criteria / total cleaved embryos |
| Cancellation rate | 5:6 days of ICSI | percentage of blast transfer cases who did not achieve blast stage (cancelled cases) / total number of blast stage cases |
Countries
Egypt
Contacts
Primary ContactManar M Hozyen, MSc.
Backup ContactAmira Hassan, BSc.
Outcome results
None listed