Inclusive Invasive Physiological Assessment in Angina Syndromes Registry

Conditions

Coronary Artery Disease, Microvascular Coronary Artery Disease

Keywords

Coronary flow reserve, Fractional flow reserve, Microvascular resistance, Thermodilution, Doppler flow velocity

Brief summary

This study evaluates the prognostic value and potential therapeutic impact of combined pressure and flow measurements in the evaluation of epicardial coronary stenosis and microvascular function.

Detailed description

ILIAS registry is a global effort to gather lesion-level data on the diagnostic and prognostic value of combined coronary pressure and flow measurements in clinical practice. Data is gathered from 7 nations (The Netherlands, Korea, Japan, Spain, Italy, Denmark, USA), using either coronary Doppler velocity measurements or coronary thermodilution measurements to obtain invasive coronary flow assessment. Patient treatment was governed by the local clinical practice guidelines at the time of the invasive procedure, but was at the operator's discretion. A standardized data collection sheet was used and all study adopted standardized definition of patient's baseline characteristics, clinical outcomes, and physiologic data. In case of acute coronary syndrome (unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction), only non-culprit vessel evaluation was used.

Coen K.M. Boerhout, Mauro Echavarría‐Pinto, Guus A. de Waard, Joo Myung Lee, Hernán Mejía‐Rentería et al. (31 authors)

EuroIntervention2024-06-016 citations

10.4244/eij-d-23-00713

Abnormal physiological findings after FFR-based revascularisation deferral are associated with worse prognosis in women.

Hoshino M, van de Hoef TP, Lee JM, Hamaya R, Kanaji Y, Boerhout CKM, de Waard GA, Jung JH, Lee SH, Mejia-Renteria H, Echavarria-Pinto M, Meuwissen M, Matsuo H, Madera-Cambero M, Eftekhari A, Effat MA, Marques K, Doh JH, Christiansen EH, Banerjee R, Nam CW, Niccoli G, Murai T, Nakayama M, Tanaka N, Shin ES, Sasano T, Appelman Y, Beijk M, Knaapen P, van Royen N, Escaned J, Koo BK, Piek JJ, Kakuta T.

2023-01-191 citations

10.1038/s41598-023-28146-6

Combined use of hyperemic and non-hyperemic pressure ratios for revascularization decision-making: From the ILIAS registry.

Boerhout CKM, de Waard GA, Lee JM, Mejia-Renteria H, Lee SH, Jung JH, Hoshino M, Echavarria-Pinto M, Meuwissen M, Matsuo H, Madera-Cambero M, Eftekhari A, Effat MA, Murai T, Marques K, Doh JH, Christiansen EH, Banerjee R, Nam CW, Niccoli G, Nakayama M, Tanaka N, Shin ES, Chamuleau SAJ, van Royen N, Knaapen P, Escaned J, Kakuta T, Koo BK, Piek JJ, van de Hoef TP.

2022-11-115 citations

10.1016/j.ijcard.2022.11.015

Prognostic value of structural and functional coronary microvascular dysfunction in patients with non-obstructive coronary artery disease; from the multicentre international ILIAS registry

Coen Boerhout Boerhout, Guus A. de Waard, Joo Myung Lee, Hernán Mejía‐Rentería, Seung Hun Lee et al. (31 authors)

EuroIntervention2022-10-01106 citations

10.4244/eij-d-22-00043

Prognostic Impact of Coronary Flow Reserve in Patients With Reduced Left Ventricular Ejection Fraction

Hyun Sung Joh, Doosup Shin, Joo Myung Lee, Seung Hun Lee, David Hong et al. (73 authors)

Journal of the American Heart Association2022-07-259 citations

10.1161/jaha.122.025841

Combined Assessment of FFR and CFR for Decision Making in Coronary Revascularization: From the Multicenter International ILIAS Registry.

van de Hoef TP, Lee JM, Boerhout CKM, de Waard GA, Jung JH, Lee SH, Mejía-Rentería H, Hoshino M, Echavarria-Pinto M, Meuwissen M, Matsuo H, Madera-Cambero M, Eftekhari A, Effat MA, Murai T, Marques K, Doh JH, Christiansen EH, Banerjee R, Nam CW, Niccoli G, Nakayama M, Tanaka N, Shin ES, van Royen N, Chamuleau SAJ, Knaapen P, Escaned J, Kakuta T, Koo BK, Piek JJ.

2022-05-0118 citations

10.1016/j.jcin.2022.03.016

Clinical Relevance of Ischemia with Nonobstructive Coronary Arteries According to Coronary Microvascular Dysfunction

Seung Hun Lee, Doosup Shin, Joo Myung Lee, Tim P. van de Hoef, David Hong et al. (72 authors)

Journal of the American Heart Association2022-04-2750 citations

10.1161/jaha.121.025171

Differential Prognostic Value of Revascularization for Coronary Stenosis With Intermediate FFR by Coronary Flow Reserve.

Kim J, Shin D, Lee JM, Lee SH, Hong D, Choi KH, Hwang D, Boerhout CKM, de Waard GA, Jung JH, Mejia-Renteria H, Hoshino M, Echavarria-Pinto M, Meuwissen M, Matsuo H, Madera-Cambero M, Eftekhari A, Effat MA, Murai T, Marques K, Doh JH, Christiansen EH, Banerjee R, Kim HK, Nam CW, Niccoli G, Nakayama M, Tanaka N, Shin ES, Chamuleau SAJ, van Royen N, Knaapen P, Koo BK, Kakuta T, Escaned J, Piek JJ, van de Hoef TP, ILIAS Registry Investigators.

2022-04-279 citations

10.1016/j.jcin.2022.01.297

Interventions

DIAGNOSTIC_TESTResting distal coronary to aortic pressure ratio, Fractional flow reserve, Coronary Flow Reserve, Microvascular resistance

Calculation of the resting mean distal coronary to aortic pressure ratio (resting Pd/Pa), fractional flow reserve (Pd/Pa at hyperemia), Coronary flow reserve (peak flow/resting flow), microvascular resistance (Pd/flow).

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* underwent combined measurements of coronary pressure and flow for at least 1native coronary artery

Exclusion criteria

* hemodynamic instability * culprit vessel of acute coronary syndrome

Design outcomes

Primary

Measure	Time frame	Description
Major adverse cardiac events	10 years	Cumulative incidence of a composite of any death, any myocardial infarction, or any ischemia-driven revascularization

Secondary

Measure	Time frame	Description
Target vessel failure	10 years	Cumulative incidence of a composite of cardiac death, target-vessel related myocardial infarction, or target-vessel revascularization
Individual components of MACE and TVF	10 years	Cumulative incidence of the individual components of MACE and TVF

Countries

Denmark, Italy, Japan, Netherlands, South Korea, Spain, United States

Outcome results

None listed