Covid19
Conditions
Keywords
COVID19 IGg
Brief summary
The objective of this study is to detect the evidence on the immune response following acute SARS-CoV-2 infections. the study will report the profile of IgG specific antibodies levels to SARS-CoV-2 infection found in recovered coronavirus disease (COVID-19) patients after infection for both symptomatic and asymptomatic patients.
Detailed description
A total of 30 COVID-19 patients for the study will be enrolled. All the patients enrolled were confirmed to be infected with SARS-CoV-2 by RT-PCR assay for nasal and pharyngeal swab specimens. For the study, serum samples of the 30 patients will be collected and will be investigated for the detection rate for immunoglobulin G (IgG). The first sample will be collected 2 weeks after the second negative RT-PCR assay for nasal and pharyngeal swab specimens and 6 samples will be collected after that for 6 months later; one serum sample tested every month for 6 months after. The following questions will be addressed:- 1. What proportion of confirmed cases develops specific IgG antibodies to SARS-CoV-2? 2. How long is the duration of detection of serum IgG antibodies and antibody titres over time following infection with SARS-CoV-2?
Interventions
None listed
Sponsors
Sohag University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients with recent COVID- 19 infection(2 weeks after the second negative RT-PCR assay)
Exclusion criteria
* patients on immune-suppressive therapy * patients with immunological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rising titre of IGg antibodies | first month | it's expected to have COVID-19 antibodies within 1month of infection the antibody titre expected to rise the fall to a lower levels |
Countries
Egypt
Outcome results
None listed