Caffeine
Conditions
Brief summary
The mechanism of methylxanthines is thought to increase chemoreceptor responsiveness to CO2 in central nervous system. Besides, effect of methylxanthines on diaphragmatic contractility has also been found in experimental studies. A study of premature newborns has showed caffeine increase diaphragmatic activity and tidal volume. But, there is limited data about caffeine direct effect on diaphragma. Objective: The investigators aimed to show the direct effect of caffeine on diphragmatic contractility. Method: The babies under 32 weeks with respiratory support, are being enrolled in this study if caffeine treatment is decided to receive. Evaluation of muscle contraction is being made by ultrasound before and 30 minutes after caffeine loading dose. Right and left sides of diaphragm thickness are being measured by two clinicians on B mode ultrasound by anterior subcostal view. The velocity before and after caffeine administration will be calculated, dividing excursion frequency (parameter) for inspiratory time. Movement of the diaphragm at inspiratory and expiratory phases are also observed on M mode and the difference between the two phases are measured.
Interventions
DRUGCaffeine citrate
diaphragm contractility after administration
Sponsors
Hacettepe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 7 Days
Healthy volunteers
No
Inclusion criteria
* newborns under 32 weeks with respiratory support * caffeine is decided to give
Exclusion criteria
* babies with congenital malformations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| diphragmatic contractility | 30 minutes | diphragmatic contractility measured by ultrasonographic evaluation |
Countries
Turkey (Türkiye)
Contacts
Primary ContactHasan Tolga Celik, MD
Outcome results
None listed