Cytokines, Cytokine Storm
Conditions
Keywords
Covid-19, IL-1 beta, IL-6, TNF alpha, Omega-3, n-3FA, uninfected
Brief summary
The trial was designed to assess the effect of daily dose of 300 mg omega-3 supplements for 2 months on the selected interleukins levels in uninfected people with Covid-19.
Detailed description
Omega-3 Fatty Acids (Omega-3) are long poly unsaturated fatty acids that can be found in plants and fish, its refer to a group composed of three type of fatty acids called: Eicosapentaenoic acid (EPA), Alpha-linoleic acid (ALA), and Docosahexaenoic acid (DHA) . The health promoting effect of n-3FA may be due to immune modulating and anti-inflammatory actions . The anti-inflammatory properties of n-3FA are used for treatment of the inflammatory diseases such as irritable bowel syndrome, rheumatoid arthritis, eczema, and psoriasis . Many studies reported a significant reduction in the risk of cancers in breast, prostate, ovaries with supplementation of n-3FA (Larsson et al. 2004) .However, high-doses omega-3 supplements such as 1000 mg/day are widely spread in community pharmacies in Jordan . Currently , community pharmacy around the world are facing the challenge of increased demand for care of uninfected people with Covid -19. Accordingly , the current randomized clinical trial was designed to evaluate the effect of daily 300 mg of omega 3-FA supplements on the immune health status of uninfected people with Covid-19 as a part of as a part of preventive health care . Therefore , this RCT aims to assess whether regular daily dose of regular daily dose of omega 3-FA (300 mg) for 2 months supplementation against COVID-19 infection as a part of preventive treatment protocol in uninfected Jordanian peoples. The investigators hypothesize that the regular dose of omega 3-FA (300 mg) /day for 2 months will significantly change immune responses compared with the control group.
Interventions
DIETARY_SUPPLEMENT300 mg of omega3-FA
The participant will receive 1,000 mg of wild salmon and fish oil complex once daily, which contains 300 mg of omega3-FA. Baseline and follow-up serum levels of IL-1,IL-6, and TNF will be measured.
Sponsors
Applied Science Private University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 66 Years
Healthy volunteers
Yes
Inclusion criteria
* Inclusion criteria included males and females in the age range of 30-66 years without a medical diagnosis of COVID-19 infection.
Exclusion criteria
*
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IL-1 beta | (2 months ; 60 days ) | pg/mL |
| IL-6 | (2 months ; 60 days ) | pg/ml |
| TNF alpha | (2 months ; 60 days ) | pg/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipid profile | (2 months ; 60 days ) | mg/dL |
| Fasting blood glucose | (2 months ; 60 days ) | mg/dl |
Countries
Jordan
Outcome results
None listed