Lidocaine, Pain, Postoperative
Conditions
Brief summary
Management of postoperative pain in 2020 remains a challenge for anesthesiologists in the perioperative period. Lidocaine is an amide local anesthetic, it is one of the oldest adjuvant analgesics and is known to possess analgesic, anti-hyperalgesic and anti-inflammatory properties. Lidocaine is proven to be as effective as epidural analgesia in colorectal surgery. However, no study has evaluated the effect of a continuous lidocaine infusion for open lung resection in the post-operative period. The present study aims to evaluate the influence of IV lidocaine given during and 24 hours after surgery, on pain scores, opioid consumption, and possible benefits on patient outcome via the opioid-sparing effect in open thoracic surgery
Interventions
DRUGLidocaine Iv
Patients in the Lidocaine group received a bolus of lidocaine 1% 1.5mg/kg at the induction of general anesthesia followed by a continuous infusion of lidocaine 1% 2mg/kg/h just before surgical incision and continued until 24h after the surgery
DRUGNormal Saline
Patients in Group Placebo received an equal bolus volume of normal saline solution at induction, and then a continuous infusion started before surgical incision and maintained up until 24h postoperatively
Sponsors
Saint-Joseph University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* American society of anesthesiologists (ASA) scores of I, II or III. * Left or right posterolateral thoracotomy with postoperative monitoring in the intensive care unit (ICU) for at least 24 hours (h).
Exclusion criteria
* patient's refusal to participate * ASA score of IV or higher * severe hepatic or renal insufficiency * allergy to lidocaine, morphine or NSAIDs * cardiac arrhythmias or * epilepsy, * delayed extubation for more than 2 h postoperatively * urgent surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Opioid consumption in the post operative period | Doses were measured for twenty four hours in the post operative period | Total dose of morphine in the post operative period is measured for patients in both arms |
| Pain scores at rest and at cough | Measurements were made for 24 hours in the post operative period | Analogue visual scale ( a 10cm scale , zero representing no pain and 10 representing the worst imaginable pain)) was used to measure pain scores for each patient at rest and at cough |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary complications | Measurements were recorded for 24 hours in the post operative period | Arterial partial carbon dioxide pressure (PCO2) measurements were recorded for patients in both arms |
Countries
Lebanon
Outcome results
None listed