Brazilian Registry for Clinical Presentation of Individuals With COVID-19 (SARS-Brazil)

Conditions

Covid19, SARS-CoV Infection

Keywords

COVID-19, SARS-CoV2 infection, Intensive care unit, Oxygen supplementation, Invasive ventilation, Mortality

Brief summary

This is a registry-based cohort study of all adult patients (≥18 years) with confirmed or suspected SARS-CoV-2 infection. The main goal is to describe mortality incidence, demographic characteristics, coexisting conditions, treatments, outcomes among SARS-CoV2 infected patients. A secondary goal is to identify biological factors (OMICS - genomic, proteomic and metabolomics characterization) associated with severity conditions for these patients.

Detailed description

Registry on characteristics and outcomes of hospitalized and non-hospitalized SARS-CoV2 infected patients in Brazil.

Fonseca HAR, Pereira AJ, Pereira AJ, Nawa RK, Sant'Anna VAR, Almeida TF, Guimarães HP, Tognon AP, Marques LM, Silva LSCD, Bittencourt RS, Gomes CP, Martins PA, Oliveira AL, Milan EP, Dall'Orto FTC, Hoffman Filho CR, Almeida G, Hohmann FB, Moia DDF, Piano LPA, Machado FP, Soares RVP, Damiani LP, Assis SRL, Amaro Junior E, Rizzo LV, Berwanger O.

2024-08-09

10.31744/einstein_journal/2024ao0652

The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics.

Schons M, Pilgram L, Reese JP, Stecher M, Anton G, Appel KS, Bahmer T, Bartschke A, Bellinghausen C, Bernemann I, Brechtel M, Brinkmann F, Brünn C, Dhillon C, Fiessler C, Geisler R, Hamelmann E, Hansch S, Hanses F, Hanß S, Herold S, Heyder R, Hofmann AL, Hopff SM, Horn A, Jakob C, Jiru-Hillmann S, Keil T, Khodamoradi Y, Kohls M, Kraus M, Krefting D, Kunze S, Kurth F, Lieb W, Lippert LJ, Lorbeer R, Lorenz-Depiereux B, Maetzler C, Miljukov O, Nauck M, Pape D, Püntmann V, Reinke L, Römmele C, Rudolph S, Sass J, Schäfer C, Schaller J, Schattschneider M, Scheer C, Scherer M, Schmidt S, Schmidt J, Seibel K, Stahl D, Steinbeis F, Störk S, Tauchert M, Tebbe JJ, Thibeault C, Toepfner N, Ungethüm K, Vadasz I, Valentin H, Wiedmann S, Zoller T, Nagel E, Krawczak M, von Kalle C, Illig T, Schreiber S, Witzenrath M, Heuschmann P, Vehreschild JJ, NAPKON Research Group.

2022-07-2940 citations

10.1007/s10654-022-00896-z

Interventions

OTHERHospital admission

Usual care.

OTHERNon-hospitalization procedures

Usual care.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Adult patients (≥18 years); * Confirmed or suspected SARS-CoV2 infection

Exclusion criteria

* Patient who expressed opposition to participation in the study

Design outcomes

Primary

Measure	Time frame	Description
All-cause mortality	60 Days	All-cause mortality rates at 60 days

Secondary

Measure	Time frame	Description
Hospitalizations	60 Days	Rate of patients requiring hospitalization and re-hospitalization (readmission to the hospital occurring within 60 days after admission)
Oxygen supplementation	60 Days	Rate of patients requiring oxygen therapy
Use of invasive mechanical ventilation	60 Days	Rate of patients requiring invasive mechanical ventilation
Intensive care unit length of stay	60 Days	ICU length of stay
Incidence and course of symptoms of COVID-19 infection	60 Days	To assess the prevalence and course of symptoms of COVID-19 infection of patients followed during a period of 60 days

Other

Measure	Time frame	Description
Genomic description	60 Days	Determination of whole genome sequence and transcriptomic of mild or moderate to severe disease
Serum metabolomic	60 Days	Percentual changes in serum metabolome of patients with mild or moderate to severe disease
Serum proteomic	60 Days	Percentual changes in serum proteome of patients with mild or moderate to severe disease

Countries

Brazil

Outcome results

None listed