Fluorodeoxyglucose, Lung Neoplasm, Lymphoma, Melanoma, Positron-emission Tomography
Conditions
Brief summary
To determine the minimum scan duration for fluorine-18 positron-emitting radioactive isotope-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scans performed on a total-body PET/CT scanner that results in non-inferior image quality to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner. The subject population will be patients being staged for lung cancer, lymphoma, or melanoma.
Interventions
DEVICEuEXPLORER/mCT
Participants will undergo a total-body PET/CT scan with the uEXPLORER scanner first, followed by a PET/CT scan with the conventional mCT PET/CT scanner.
DEVICEmCT/uEXPLORER
Participants will undergo a PET/CT scan with the conventional mCT PET/CT scanner, followed by a total-body PET/CT scan with the uEXPLORER scanner
Sponsors
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Ability to understand and willingness to sign an informed consent form. 2. Ability to adhere to the study visit schedule and all protocol requirements. 3. Men and women ≥18 years of age. 4. Diagnosis or suspected diagnosis of lung cancer, melanoma or lymphoma. 5. Patients who have been referred for a PET/CT scan.
Exclusion criteria
1. Pregnant women. 2. Claustrophobia. 3. Any significant medical condition that in the opinion of the investigator would prevent the subject from participating and/or adhering to study related procedures or interfere with subject safety.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Minimum scan duration on a total-body PET/CT scanner for quality | One imaging visit up to two hours | To determine the minimum scan duration for 18F-FDG PET/CT scans performed on a total-body PET/CT scanner that results in non-inferior image quality to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner over 20 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Minimum scan duration on a total-body PET/CT scanner for tumor recognition | One imaging visit up to two hours | To determine the minimum scan duration for 18F-FDG PET/CT scans performed on a total-body PET/CT scanner that results in non-inferior tumor conspicuity to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner over 20 minutes (with an additional 2 minutes of data used for optimization purposes). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORLorenzo Nardo, MD
UC Davis Department of Radiology
Outcome results
None listed