Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

Screening of Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04477564

Acronym

CHIPS

Enrollment

150

Registered

2020-07-20

Start date

2020-07-03

Completion date

2023-06-13

Last updated

2025-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Venous Thromboembolism

Keywords

Clonal Hematopoiesis of indeterminate potential

Brief summary

The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism. The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism * Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107))

Exclusion criteria

* Patients less than 50 years old * Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism

Design outcomes

Primary

Measure	Time frame	Description
DNMT3A mutations screening	For sequencing analysis: 2 months	Next generation sequencing

Secondary

Measure	Time frame	Description
TET2, ASXL1, TP53, JAK2, SF3B1, SRSF2, GNB1, CBL, BCOR, SH2B3, PPM1D mutations screening	For sequencing analysis: 2 months	Next generation sequencing

Countries

France

Outcome results