Coma, Consciousness Disorder, Covid19
Conditions
Brief summary
The primary aim of this research proposal is to use multimodal metrics (e.g., clinical data and advanced neuroimaging) in the early (i.e., acute hospitalization) phase of recovery from COVID-19-related disorders of consciousness to predict outcome at 3, 6, and 12 months post-hospitalization. We aim to construct an algorithm that synthesizes the results of these metrics to help predict recovery.
Interventions
DIAGNOSTIC_TESTFunctional MRI
measurement of functional brain networks
Sponsors
Massachusetts General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
1. age 18 or older, 2. positive diagnosis of COVID-19, 3. diagnosis of coma, vegetative state or minimally conscious state per Glasgow Coma Scale (GCS) at time of enrollment (excluding confounders such as sedation) and 4. clinical team plan for an MRI for clinical management.
Exclusion criteria
A subject with any of the following MRI contraindications will not be eligible for this study: * electrical implants such as cardiac pacemakers or perfusion pumps * ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants * ferromagnetic objects such as jewelry or metal clips in clothing that cannnot be easily removed for scanning * pregnant volunteers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disability Rating Scale score | 6 months | Functional outcome measure. Maximum score of 29 represents high disability, minimum score of 0 represents no disability. Higher scores represent higher level of disability. |
Countries
United States
Outcome results
None listed