Use of PRF in Treatment of Dry Socket.

Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04476121

Enrollment

Registered

2020-07-17

Start date

2019-01-01

Completion date

2021-07-01

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Osteitis

Keywords

dry socket, PRF

Brief summary

The aim of the study is to evaluate the influence of PRF application in case of alveolar osteitis.

Detailed description

The main objective was to compare the effects of using two different methods in the treatment of dry socket (alveolar osteitis), which is a postoperative complication of dental extraction. The first was Nipas, applied, if dry socket was diagnosed following a tooth extraction. In case of subsequent extraction of homonymous tooth and reoccurrence of dry socket, patients were treated with application of PRF.

Interventions

PROCEDUREPRF application

PRF application into post-operative wound.

DRUGNipas application

Nipas application into post-operative wound.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

The first medicine was applied, if dry socket was diagnosed following a tooth extraction. In case of subsequent extraction of homonymous tooth in the same patient and reoccurrence of dry socket, patients were treated with PRF application.

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* no known medical history of abnormal platelet counts, * patients with symmetric teeth qualified for extraction,

Exclusion criteria

* patients treated previously for existing dry socket, * patients allergic to acetylsalicylic acid , * systemic diseases, * pregnancy, * lactation, * drugs known to affect the number or function of platelets, * abnormal platelet counts,

Design outcomes

Primary

Measure	Time frame	Description
Intensity of pain vs. PRF and Nipas application	24 hours	In order to evaluate the relationship between intensity of pain after application of PRF and Nipas, Numeric Rating Scale pain scale is used. NRS is a horizontal line with an eleven point numeric range. It is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible. The higher score means worse outcome in case of present study.
Influence of treatment on bacteria levels in wounds	24 hours	The second part of the study was dedicated to analyzing the number of bacteria in tooth extraction wounds.

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026