Follow-up of Critical COVID-19 Patients

Conditions

AKI, ARDS, Circulatory Failure, Coagulation Disorder, COVID19, Inflammatory Response

Keywords

Corona virus, Acute Kidney Injury, SARS, Vasopressor, Respiratory failure

Brief summary

The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19. Blood and urine will be collected for biobanking.

Detailed description

The study will follow COVID-19 patients who required intensive care at Uppsala University Hospital and were included in the Uppsala COVID-19 biobank. The patients will be contacted after three to six months for a first follow-up with assessment of functional level in activities of daily life, psychiatric symptoms, neurological symptoms and working capacity as well as specific organ functions. The organ functions will include circulation, respiration, coagulation, immune function and kidney function. In addition, blood and urine will be collected for biobanking.

Kristin Jona Bjarnadottir, Gaetano Perchiazzi, Caroline Lördal Sidenbladh, Aleksandra Larina, Ewa Wallin et al. (15 authors)

Frontiers in Physiology2024-07-103 citations

10.3389/fphys.2024.1399407

Halvorsen P, Hultström M, Hästbacka J, Larsson IM, Eklund R, Arnberg FK, Hokkanen L, Frithiof R, Wallin E, Orwelius L, Lipcsey M.

2023-10-2110 citations

10.1038/s41598-023-45346-2

Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.

Bark L, Larsson IM, Wallin E, Simrén J, Zetterberg H, Lipcsey M, Frithiof R, Rostami E, Hultström M.

2023-08-1222 citations

10.1038/s41598-023-39698-y

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklós Lipcsey, David Morrison, Tomoko Nakanishi, Guillaume Butler‐Laporte et al. (17 authors)

Critical Care2022-10-2116 citations

10.1186/s13054-022-04203-w

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* PCR-verified Covid-19 * Treated in ICU

Exclusion criteria

* Pregnant of breastfeeding

Design outcomes

Primary

Measure	Time frame	Description
Mortality	Within 90 days after admission to ICU.	Death
Renal recovery	At follow-up three to six months after ICU discharge.	Return of renal function measured as CKD stage.
Respiratory recovery	Three to six months from discharge from ICU	Respiratory function as assessed by a clinician
Working capacity	Three to six months from discharge from ICU	6 min walk test
Quality of life score	Three to six months from discharge from ICU	Quality of Life assessed using the 36-item short form survey by RAND.
Cognitive recovery	Three to six months from discharge from ICU	Cognitive screening using the Montreal Cognitive Assessment.
Frailty	Three to six months from discharge from ICU	Screening for frailty using the Clinical Frailty Scale-9.
Activities of Daily Life	Three to six months from discharge from ICU	Screening of functional level for Activities of Daily Life using the 5-level EQ-5D.
Anxiety	Three to six months from discharge from ICU	Screening for anxiety using the Generalised Anxiety Disorder 7-item scale.
Depression	Three to six months from discharge from ICU	Screening for depression using the Patient Health Questionnaire 9.
Neurological recovery	Three to six months from discharge from ICU	Neurological function as assessed by a clinician

Countries

Sweden

Contacts

Primary ContactMichael Hultström, MD. PhD.

michael.hultstrom@mcb.uu.se+46186110000

Backup ContactRobert Frithiof, MD. PhD.

robert.frithiof@surgsci.uu.se+46186110000

Outcome results