Anesthesia
Conditions
Keywords
Anesthesia, Endoscopy, Colonoscopy
Brief summary
Conscious sedation provides adequate control of pain and anxiety for the majority of routine endoscopic procedures as well as adequate amnesia. Sedation practices vary widely, with some colonoscopists advocating sedation only for the most difficult cases of colonoscopy, while others prefer using deep sedation or general anaesthesia for colonoscopy. However, many physicians are still using moderate sedation for the majority of patients. The use of propofol, a short acting anesthetic agent, for conscious sedation provides a considerably more rapid onset of action and shorter recovery time, for which it is believed to be a safe drug of choice for patients undergoing endoscopic procedures. Although propofol cannot be used as a single agent for moderate sedation, it can be effectively titrated to moderate sedation after administration of small doses of narcotics and sedatives. The aim of this study is to compare between general anesthesia and deep sedation using propofol-fentanyl-ketamine (PFK) preparation in terms of perioperative vital signs, intraoperative awareness, post-operative pain scores, and the use of analgesia postoperatively.
Interventions
DRUGPK general anesthesia
Patients will be anesthetized using Fentanyl (2 mcg/kg) and Propofol (1-2 mg/kg).
DRUGPFK combination
Each patient received an initial dose of 0.05 ml/kg from the solution, then after waiting for 60 seconds, another 0.05 ml/kg were given. Maintenance was given as boluses of 0.025 ml/kg every three to five minutes.
Sponsors
University of Jordan
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* patients who were admitted for endoscopic and colonoscopic procedures. * ASA (American Society of Anaesthesiologists physical status) score from 1 to 3.
Exclusion criteria
* patient refusal. * urgent and emergency cases, which were not elective procedures. * Surgeries that were expected to take a long duration (more than 1.5 hour).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transient decrease in oxygen saturation | 1 hour | the investigators will record any episodes of transient reduction of oxygen saturation. |
| Blood pressure stability | 1 hour | the investigators will record changes in blood pressure after induction of anesthesia |
| Recovery time | 2 hours | the investigators will document recovery time in the post anesthesia care unit (PACU) until recovery of full consciousness. |
Countries
Jordan
Contacts
Primary ContactAbdelkarim S AlOweidi
Outcome results
None listed