Colorectal Adenoma, Colorectal Cancer, Colorectal Neoplasm
Conditions
Keywords
Colorectal Adenoma, Colorectal Neoplasms, Occult Bleeding, quantitative fecal immunochemical test, Colorectal Cancer
Brief summary
Early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. Because of the less bleeding of advanced adenomas, the sensitivity of existing quantitative fecal immunochemical test (qFIT) is unsatisfying. A new technology qFIT, which have a higher sensitivity in extremely low concentration of hemoglobin compared with existing commercially available qFIT, is developed and this study will prove the high diagnostic accuracy in detecting colorectal advanced adenoma.
Detailed description
Colorectal cancer accounts for approximately 10% of all annually diagnosed cancers and cancer-related deaths worldwide. With progress of developing countries, it is predicted that the incidence of colorectal cancer worldwide will increase to 2.5 million new cases in 2035. The majority of colorectal cancer is thought to arise from precancerous lesions through the adenoma-carcinoma pathway. Detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer. Although colonoscopy is currently considered the most effective method for detecting advanced adenomas, individuals may be reluctant to undergo colonoscopy due to the uncomfortable feeling and the relatively high cost of colonoscopy. Conversely, stool tests are relatively cheap and more readily accepted. Annual fecal immunochemical test (FIT), one of the preferred methods of colorectal cancer screening, is economic and easy to use. However, the existing commercially available qFIT is insufficiently sensitive to the minor hemorrhage of advanced adenomas, and the sensitivity is about only 27% to 47%. To improve diagnostic accuracy in detecting colorectal advanced adenoma, an improved technology of qFIT, which have a higher sensitivity in extremely low concentration of hemoglobin in stool compared with existing commercially available qFIT, is developed. The investigators design this research to prove the diagnostic accuracy of the new qFIT in detecting colorectal advanced adenoma.
Interventions
DIAGNOSTIC_TESTThe new qFIT and colonoscopy with pathological examination
Detect hemoglobin in stool by the new qFIT before colonoscopy, detect colon lesion using colonoscopy and pathological examination.
Sponsors
Shandong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* 50-75 years old people; * People sign an informed consent form
Exclusion criteria
* People with history of surgery in any part of the large bowel; * People with history of colorectal cancer; * People with history of other diseases that may produce fecal blood, such as active diverticulitis, inflammatory bowel disease, ischemic enteritis, vascular malformation of intestine, intestinal tuberculosis or Non-Hodgkin's lymphoma involving digestive tract; * People with symptoms including visible rectal bleeding, hematuria, hemorrhoid bleeds, severe and acute diarrhea and 7th type stool (Bristol feces score); * People are in pregnancy, lactation or menstrual phase; * People with severe congestive heart failure or other sever disease cause cannot tolerate colonoscopy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The accuracy of the new qFIT to diagnose colorectal advanced adenoma. | 18 months | The sensitivity, specificity, positive predictive value and negative predictive value. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The accuracy of the new qFIT to diagnose colorectal cancer. | 18 months | The sensitivity, specificity, positive predictive value and negative predictive value. |
| Develop a predictive model of advanced colorectal neoplasms which includes the value of qFIT. | 18 months | Develop a predictive model of advanced colorectal neoplasms which includes the value of qFIT, age , sex, colorectal cancer family history, diet and so on. |
Countries
China
Outcome results
None listed