Type2 Diabetes
Conditions
Brief summary
non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.
Detailed description
Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis. Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.
Interventions
PROCEDUREnon-surgical periodontal therapy
supra and subgingival debridement
Sponsors
Cairo University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
group1: diabetic patients with chronic periodontitis group2: non diabetic patients with chronic periodontitis
Eligibility
Sex/Gender
ALL
Age
40 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosed with moderate to severe chronic periodontitis. * Presence of a minimum of 15 natural teeth * Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm * agreement to participate in the study and sign a written informed consent
Exclusion criteria
* Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation * A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months * Pregnancy or use of contraceptives or any medication related to diabetes * former or current smokers ˂ 5 years.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum resistin | 3 months | ng/ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| C-reactive protein | 3 months | μg/mL |
| probing pocket depth | 3 months | mm |
| clinical attachment loss | 3 months | mm |
Countries
Egypt
Outcome results
None listed