COVID-19 in Patients With Anosmia in Egypt

Detection of SARS-CoV-2 in Patients Presenting With Anosmia During COVID-19 Pandemic Era in Egypt

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04473157

Enrollment

Registered

2020-07-16

Start date

2020-07-01

Completion date

2020-12-30

Last updated

2021-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anosmia, Covid19, Dysgeusia

Keywords

Corona virus, SARS-CoV-2, Olfactory Disturbance, Taste Disturbance

Brief summary

The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.

Detailed description

Fifty Patients presenting to Triage and/or Ear, Nose and Throat (ENT) clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- September 2020; will undergo thorough history taking, clinical assessment and polymers chain reaction rt-PCR to SARS-COV2; and if proven negative to COVID 19, PCR to other respiratory pathogens will be tested. COVID-19 patients will be managed according to the standard protocol of Ain Shams University Hospitals. Follow up after 3 weeks for the outcome of recovery of the smell sense and seroconversion by rapid test for immunoglobulins IgM/ IgG of COVID 19, for the probability of a false negative PCR at initial visit. Ethical committee approval for the current study protocol was obtained. Patients will be invited to participate and the informed consent will be signed.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adult (\>18 years) patients presented with acute-onset anosmia.

Exclusion criteria

* patients with anosmia or gustatory dysfunctions before the epidemic; patients with previous history of chronic sinusitis or previous sinus surgery.

Design outcomes

Primary

Measure	Time frame	Description
Recovery from Anosmia	3 weeks	subjective questionnaire about smell and taste
Seroconversion	3 weeks	developing IgM/ IgG antibodies by rapid test

Secondary

Measure	Time frame	Description
COVID 19	3 weeks	developing other symptoms of COVID 19

Countries

Egypt

Outcome results