Cicatricial Alopecia, Hair Transplantation
Conditions
Keywords
hair loss, follicuular unit extraction, platelet rich plasma
Brief summary
follicular unit extraction as a method of hair transplantation in cicatricial alopecia
Detailed description
The study will include 20 patients with cicatrical alopecia.Patients will be randomly assigned into two groups:Group (A):include ten patients will undergo (FUE) alone. Group (B): include ten patients will undergo(FUE) and (PRP).3-Surgical technique: * Preoperative Investigations including complete blood count, coagulation profile and hepatitis viral markers. 1-Group(A): will undergo (FUE) * Washing the scalp with antiseptic shampoo before the procedure. * Tumuscentanaesthesia:The donor area is anesthetized with a lidocaine 1% solution diluted with 20 cc saline in addition to adrenaline. * Creation of micropunches(0.7-1 mm) using micromotor. * After removal of the punch,the follicular unit is extracted with Jweler's forceps. * Extracted grafts are then placed on chilled saline gauze for maximum four hours until ready for transplantation. * The recipient area is prepared with rectangular scalpel blades 1mm or hypodermic blades 0.9 mm. * Implantation using fine tipped jweler's forceps. * Finally, receptor and donor areas will be softly cleansed with saline and crepe bandage is applied. 2-Group (B): FUE+PRP * The same procedure will be done but grafts will be placed in Prp solution. * Prp session one week before transplantation then monthly for 3 monthes after (FUE). * Preparation of PRP * 10 cc blood will be aspirated in test tube contained a modified solution of anticoagulant,called acid-citrate-dextrose type (ACDA), in which the physiological pH will reached to preserve the platelet integrity. * The first spin of whole blood sample will be at 2500 rpm for 4 minutes * The second spin at 4000 for 20 minutes for obtained plasma. * Platelets are separated as a pellet at the bottom of the tube from platelet-poor plasma (PPP) above. The platelet-rich pellet is resuspended in remaining amount of plasma. The resulting suspension is used as PRP. * Prp is injected in the recipient area. 4-Follow up: * Follow up clinically by digital photographs and trichoscopy 1 week after operation, after 3 months and after 6 months.
Interventions
PROCEDUREfollicular unit extarcation and platelet rich plasma
hair transplantation procedure
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* • Patients with unacceptable visible scarring alopecia. * Adequate donor area. * patient free of signs of disease activity evidenced by trichoscopy. * Patients having inadequate laxity for a strip excision (too tight skin). * When previous scars of strip surgeries make further strips impossible.
Exclusion criteria
* • Inadequate donor area. * Signs of active disease or infection. * Patient who is not willing for long sessions for several hours or multiple sessions as needed due to the slowness of the process * Contraindications for surgical procedure as bleeding tendency. * Contraindications for PRP as (cardiovascular, autoimmune disorders, hematological disorders and neoplasms).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hair regrowth | 6 months | transplanted hair develop int new hair growth in bald area |
Countries
Egypt
Outcome results
None listed