Chronic Polypous Rhinosinusitis
Conditions
Brief summary
The essential anesthesia requirements for FESS include airway management, considerations for facilitating surgical access, provision of a clear and still surgical field for precision surgery, assuring quick and non-stimulating emergence from anesthesia, and fast-tracking patients for discharge. Postoperative agitation, although short-lived, is potentially harmful to both patients and recovery room staff, it has a potential for self-injury by removing intravenous catheters, tubing, oxygen masks and nasal packs. Furthermore, very agitated patients can pose an immediate danger to operating theatre staff.
Detailed description
Lidocaine is an amino amide-type short-acting local anesthetic (LA). It has a short half-life, and a favorable safety profile, and is therefore the LA of choice for continuous IV administration, it has analgesic, and anti-inflammatory effects that are induced by reduction of cytokines production through inhibition of neutrophil activation, and the analgesia may persist even after plasma concentration reduction. It can blunt the pressor response to endotracheal intubation also systemic lidocaine was effective in producing controlled hypotension.
Interventions
DRUGLidocaine
patients will receive a loading dose of IV lidocaine 1.5mg/kg slowly diluted with 20 ml normal saline just before induction of anesthesia, then the lidocaine infusion started at a rate of 2mg/kg/h diluted in normal saline by rate of 2 ml/ kg/h.
DRUGNormal saline
patients will receive an equal volume of normal saline (both the loading, and the infusion). The infusion in both groups will be started just after induction of anesthesia induction, and continued until the end of the operation
Sponsors
Alexandria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for elective functional endoscopic sinus surgery; * ASA class I-II, * aged (20-60 years).
Exclusion criteria
* Body mass index \>35 kg/m2 * History of allergic reaction to local anesthetic agents especially lignocaine. * History of preoperative use of opioids. * Patients with history of uncontrolled hypertension, A-V conduction block. * History of sleep apnea.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| quality of postoperative recovery | 48hours | assessed using the Quality of Recovery-40 questionnaire.8, which assesses five dimensions of recovery |
| Emergence agitation | 30 minutes postoperative | using the Richmond agitation-sedation scale |
Countries
Egypt
Contacts
Primary ContactRehab A. Abd Elaziz, Ass. Prof.
Outcome results
None listed