Covid19, Thymic Hypoplasia
Conditions
Brief summary
COVID-19 infected pregnant women is thought to have variable degrees of inflammatory response against the disease. Investigators of present study, suggested that fetuses are affected from the possible fetal inflammatory syndrome in case of maternal COVID-19. Therefore the aim of his study is to evaluate that if the cardiothymic index is affected by the maternal COVID-19 and to demonstrate any possible association of this measurement with neonatal morbidities.
Detailed description
COVID-19 infected pregnant women is thought to have variable degrees of inflammatory response against the disease. Fetus is known to be influenced by maternal systemic infections. Thymus size of fetus and the neonate, is proven to be changed by primarily inflammatory/infectious diseases. Investigators of present study, suggested that fetuses are affected from the possible fetal inflammatory syndrome in case of maternal COVID-19. Therefore the aim of his study is to evaluate that if the cardiothymic index is affected by the maternal COVID-19 and to demonstrate any possible association of this measurement with neonatal morbidities.
Interventions
DIAGNOSTIC_TESTchest x-ray
First Chest X-ray in the first 6 hours of infants
Sponsors
Kanuni Sultan Suleyman Training and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 7 Hours
Healthy volunteers
Yes
Inclusion criteria
* Infants born to COVID-19 positive or negative mothers * Accepted to participate with an informed consent * Infants who required to get chest X-ray within the first 6 hours
Exclusion criteria
* Infants whose mothers' have any kind of acute or chronic systemic disease or inflammation/infection * Lack of an informed consent * Infants who did not require to get chest X-ray within the first 6 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiothymic index | 4 months | Cardiothymic index will be measured by using the thymic shadow divided by largest diameter of mediastinum in the chest X-ray of those infants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Immune profile | 6 months | In long term follow up of those patients, infants will be evaluated for any kind of immune deficiency or quantitative or qualitative abnormalities of leukocytes |
Countries
Turkey (Türkiye)
Contacts
Primary ContactSeda Yilmaz Semerci
Outcome results
None listed