Periodontal Diseases
Conditions
Keywords
type 1 diabetes mellitus
Brief summary
The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.
Detailed description
Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.
Interventions
DIAGNOSTIC_TESTELISA
Saliva sample collection
Sponsors
Aydin Adnan Menderes University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 14 Years
Inclusion criteria
* Children diagnosed as type 1 diabetes mellitus * Age between 7-14 years
Exclusion criteria
* Having another systemic problem except type 1 diabetes mellitus * Children carrying orthodontic appliances
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular endothelial growth factor level | Baseline | Vascular endothelial growth factor level in saliva |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thiol/disulphide measurement | Baseline | Total thiol, native thiol and disulphite level in saliva |
Countries
Turkey (Türkiye)
Outcome results
None listed