Endothelial Corneal Dystrophy
Conditions
Keywords
Fuchs endothelial corneal dystrophy, central corneal thickness, endothelial cell density, keratometry
Brief summary
Aim: Identify predictive factors of good results after primary Descemet's Membrane Endothelial Keratoplasty (DMEK) in Fuchs Endothelial Corneal Dystrophy (FECD). 82 patients (102 eyes) with Fuchs Endothelial Corneal Dystrophy (FECD) underwent DMEK between March 2016 and March 2018 were analyzed. Follow-up time was 12 months. The studied prognostic criteria were: pre-operative Central Corneal Thickness (CCT), CCT's delta between pre and D15 post-operatively, anterior mean keratometry, pre-operative endothelial cell density (ECD) and postoperative ECD at 6 and 12 months, pre-operative visual acuity, donors' and recipients' ages, recipients' sex, rebubbling and triple procedure (DMEK combined with cataract surgery).
Detailed description
Aim: Identify predictive factors of good results after primary Descemet's Membrane Endothelial Keratoplasty (DMEK) in Fuchs Endothelial Corneal Dystrophy (FECD). A monocentric retrospective observational study was realized at the Regional Hospital Center of Metz-Thionville, Mercy Hospital, Metz, France. 102 eyes of 82 patients with Fuchs Endothelial Corneal Dystrophy (FECD) underwent DMEK between March 2016 and March 2018 were analyzed. Follow-up time was 12 months. The studied prognostic criteria were: pre-operative Central Corneal Thickness (CCT), CCT's delta between pre and D15 post-operatively, anterior mean keratometry, pre-operative endothelial cell density (ECD) and postoperative ECD at 6 and 12 months, pre-operative visual acuity, donors' and recipients' ages, recipients' sex, rebubbling and triple procedure (DMEK combined with cataract surgery). Surgery was considered successful when best spectacle corrected visual acuity (BSCVA) was 0.1 logMar or less (≥0.8) 1 year postoperatively.
Interventions
None listed
Sponsors
Centre Hospitalier Régional Metz-Thionville
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Over 18, * had advanced FECD associated with visual symptoms and reduced visual acuity .
Exclusion criteria
* Prior intraocular surgery other than cataract * Other indications for DMEK surgeries than FECD, * Eyes with corneal (except FECD), retinal or optic nerve diseases * Per-operative difficulties (tear's graft or complicated unfolding graft) * Primary graft failure (cornea that failed to clear in the presence of an attached graft) * Secondary graft failure (corneal decompensation after an initial period of a functional graft)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pre-operative Central Corneal Thickness (CCT), | day 1 | Pre-operative CCT (μm) measured by an anterior segment optical coherence tomography (AS-OCT; RS-3000; Nidek Co. Ltd, Japan) |
| Post-operative Central Corneal Thickness (CCT), | Months 12 | Post-operative CCT (μm) measured by an anterior segment optical coherence tomography (AS-OCT; RS-3000; Nidek Co. Ltd, Japan) |
| CCT's delta | day 15 | CCT's delta (μm) between pre and D15 post-operatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pre-operative Visual Acuity | day 1 | pre-operative Visual Acuity (using Monoyer chart and converted it to logMar scale) |
| donors' and recipients' ages | day 1 | donors' and recipients' ages |
| anterior mean keratometry | day 1 | anterior mean keratometry (calculated by an auto keratometer Visionix Luneau L67, France) |
| rate of rebubbling | months 6 | the rate of rebubbling %(postoperative graft detachment) |
| recipients' sex | day 1 | recipients' sex |
| pre-operative endothelial cell density ECD | day1 | pre-operative ECD (using a non-contact specular microscope CEM-530; Nidek Co. Ltd, Japan) |
| post-operative endothelial cell density (ECD) | 6 months | post-operative ECD at 6 months (using a non-contact specular microscope CEM-530; Nidek Co. Ltd, Japan) |
Outcome results
None listed