Impact of Sinus Surgery on Individuals With Cystic Fibrosis

Conditions

Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis

Keywords

Chronic Rhinosinusitis, Cystic Fibrosis, Endoscopic Sinus Surgery

Brief summary

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Cameran Owens, Todd Bodner, Naweed I. Chowdhury, Jeremiah A. Alt, Jakob L. Fischer et al. (34 authors)

UNC Libraries2026-07-25

10.17615/80kd-v548

Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

Christine Liu, Jakob L. Fischer, Michelle J. Lee, Jess C. Mace, Adam J. Kimple et al. (34 authors)

The Laryngoscope2025-03-291 citations

10.1002/lary.32155

Impact of sinus surgery in people with cystic fibrosis and chronic rhinosinusitis in the era of highly effective modulator therapy: Protocol for a prospective observational study

Christine Liu, Jakob L. Fischer, Jeremiah A. Alt, Todd Bodner, Naweed I. Chowdhury et al. (15 authors)

PLoS ONE2024-09-261 citations

10.1371/journal.pone.0310986

Impact of sociodemographic status and sex on chronic rhinosinusitis and olfaction in people with cystic fibrosis

Ethan J. Han, Christine Liu, Jakob L. Fischer, Jess C. Mace, Karolin Markarian et al. (31 authors)

International Forum of Allergy & Rhinology2024-07-052 citations

10.1002/alr.23402

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

No

Inclusion criteria

1. Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old). 2. Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride 3. Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines 4. chronic rhinosinusitis symptoms persisting beyond initial medical treatment 5. Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment

Exclusion criteria

1. Underwent endoscopic sinus surgery in past 12 months 2. Will obtain follow up care at non-participating institutions 3. Unable to complete follow-up surveys

Design outcomes

Primary

Measure	Time frame	Description
Change in pulmonary function	baseline, 3, 6, 9, 12 months	Pulmonary function will be measured using spirometry - the percent of predicted forced expiratory volume in the first second (ppFEV1)
Change in days of inpatient hospitalization	baseline, 3, 6, 9, 12 months	Days of inpatient hospitalization will be assessed

Secondary

Measure	Time frame	Description
Change in quality of life	baseline, 3, 6, 9, 12 months	Quality of life will be assessed using the 22-question SinoNasal Outcome test (range 0-110, with higher scores signifying worse quality of life)
Change in olfaction	baseline, 3, 6, 9, 12 months	Olfaction will be assessed using the Smell Identification Test (score range: 0-40, with higher scores demonstrated better olfactory ability)

Countries

United States

Contacts

CONTACTDaniel M Beswick, MD

dbeswick@mednet.ucla.edu310-206-8457

CONTACTMarlene Florian

mflorian@mednet.ucla.edu424-946-5862

PRINCIPAL_INVESTIGATORDaniel M Beswick, MD

University of California, Los Angeles

Outcome results