Skip to content

Intra-Abdominal Pressure Effect on Intra-Abdominal Volume and Airway Pressures During Laparoscopy

Intra-Abdominal Pressure Effect on Intra-Abdominal Volume and Airway Pressures During Pneumoperitoneum Insufflation - a Patient-Level Meta-Analysis of Three Randomized Clinical Trials

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04468698
Enrollment
204
Registered
2020-07-13
Start date
2019-01-01
Completion date
2020-07-01
Last updated
2020-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra Abdominal Pressure, Pneumoperitoneum, Surgery

Brief summary

During pneumoperitoneum insufflation the insufflated gas increase intra-abdominal pressure. The generated pressure can lead to a different increase in volume depending on the abdominal cavity and patients' characteristics. The primary objective is to determine the relationship between intraabdominal pressure (IAP) and intraabdominal volume (IAV) during pneumoperitoneum insufflation. The secondary objective is to determine the rate of abdominal-thoracic transmission (ATT) assessing the correlation between IAP and respiratory driving pressure (ΔPRS).

Interventions

OTHERPeritoneum insufflation

Before surgery pneumoperitoneum is established by insufflating gas into the abdomen. Intraabdominal pressure (IAP) is set to 15 mmHg for initial abdominal stretching and then decreased in a stepwise manner down until 8 mmHg.

Sponsors

Hospital Universitario La Fe
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Enrolled one of the three studies (IPPCollapse I, II or III). * underwent an initial insufflation procedure with a stepwise change in intraabdominal pressure to record Intraabdominal volume * data from insufflation at 5 cmH2O of PEEP

Design outcomes

Primary

MeasureTime frame
Intraabdominal volumeDuring pneumoperitoneum insufflation before surgery

Secondary

MeasureTime frameDescription
Driving pressureDuring pneumoperitoneum insufflation before surgeryThis is the pressure that exert a stress on the respiratory system during mechanical ventilation. It is calculated by subtracting the positive endexpiratory pressure from plateau pressure
Plateau pressureDuring pneumoperitoneum insufflation before surgeryThis is the pressure in the airway during the mechanical venitilation inspiratory pause time

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026