Cholecystitis
Conditions
Brief summary
Laparoscopic cholecystectomy (LC) is an easy procedure characterized by its minimal invasiveness, less post-operative pain and early recovery when compared to the open conventional cholecystectomy. However, patients who have undergone LC still complain of postoperative pain. It has been reported that ondansetron produces numbness when injected under the skin and has local anesthetic effect that is 15 times more potent than lidocaine the most widely used local anesthetic and probably explains its antiemetic action. It possesses anti-inflammatory, anesthetic, and analgesic properties by its multifaceted actions as a 5-HT3 receptor antagonist, a Na channel blocker, and a mu-opioid agonist which may have a potential role in decreasing pain. The study aimed to demonstrate the effectiveness of IP administration of ondansetron on pain management post LC.
Interventions
DRUGOndansetron
Interperitoneal administration in the gall bladder bed
DRUGNormal saline
Interperitoneal administration in the gall bladder bed
Sponsors
National Hepatology & Tropical Medicine Research Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients who are scheduled to undergo elective LC
Exclusion criteria
* Patients undergoing chronic pain treatment * Previous allergic response to local anesthetics or 5-HT3 receptor antagonists * Patients who received analgesics or sedatives 24 h before scheduled surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in postoperative pain between the two groups using visual analogue score (VAS) | 24 hours |
Countries
Egypt
Outcome results
None listed