Eating Behavior, Shift Work Type Circadian Rhythm Sleep Disorder
Conditions
Brief summary
This study will compare eating behaviors and measures of hunger and fullness between day and night workers in order to better understand why night workers are at increased risk for obesity and related diseases.
Interventions
BEHAVIORALPortion size
The amount of food served (g) at the first two meals of each day. These amounts will vary across 4 weeks.
Sponsors
Columbia University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Statistician will be blinded to participant group and condition.
Intervention model description
This is a mixed design with two participant groups (between-subject), day and night workers, each being exposed to 4 levels of food portion size (within-subjects factor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Work \~ 8-hour shifts during day or night on 3 or more consecutive days of the week * BMI 19-35 kg/m\^2 * Age 20-55 years of age * Metabolically healthy * Weight stable over previous 3 months * Lives in New York City area
Exclusion criteria
* Pregnant or less than 1 year postpartum at time of study * Smoking * History of drug or alcohol abuse * Rotating shift work * Habitual sleep duration of more than 6 hour per night * Obstructive sleep apnea * Transmeridian travel * Type 2 diabetes * Cardiovascular disease * Hypertension * Participation in diet or weight loss program in the 3 months prior to enrollment * Psychiatric or sleep disorder * Food allergies or intolerances * Dislike of or unwillingness to eat test foods
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Food intake | 24-hours intake period | Food by weight (g) in response to variations in portion served |
| Energy intake | 24-hours intake period | Food by energy (kcal) in response to variations in portion served |
| Energy density consumed | 24-hours intake period | Energy density consumed (kcal/g) in response to variations in portion served |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Appetite-regulating hormones | 2-hours measurement period | Appetite-regulating hormones, including Glucagon-like-peptide 1 (GLP-1) and ghrelin will be analyzed from plasma from whole blood samples collected while fasted and at 30, 60, 90, and 120 min postprandial. Area under the curve of plasma concentrations will be calculated for each individual appetite-regulating hormone |
| Hunger and fullness | 24-hours measurement period | Subjective measures related to hunger, fullness, and prospective consumption will be measured before and after meals via visual analog scales. The range of scores are 0 mm to 100 mm, with higher scores indicating greater feelings of the corresponding measure (e.g. greater hunger). Post-meal measures, adjusted for the corresponding pre-meal measure, will be analyzed as individual outcomes. Area under the curve will also be calculated for each measure. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORFaris M Zuraikat, PhD
Columbia University
PRINCIPAL_INVESTIGATORMarie-Pierre St-Onge, PhD
Columbia University
Outcome results
None listed