Healthy
Conditions
Brief summary
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
Interventions
OTHERSaline
Saline will serve as the control
BIOLOGICALExendin-9,39
Exendin-9,39 will block the GLP-1 receptor
Sponsors
Adrian Vella
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 40 nondiabetic subjects will be recruited. * 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype. * Individuals encompassing the age span of 25-65 years.
Exclusion criteria
* Individuals under 25 and over 65 years of age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ) | This will be calculated from the 0-180 minute data of the study |
Secondary
| Measure | Time frame |
|---|---|
| Glucagon secretion measured by immunoassay | This will be averaged over the 0-180 minute data of the study |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAdrian Vella, MD
Mayo Clinic
Outcome results
None listed