Large Bone Defects
Conditions
Keywords
large bone defects, 3D printed individualized porous implant, implant-bone interface fusion
Brief summary
The aim of this study was to investigate the simply use of three-dimensional (3D) printed individualized porous implants in the absence of autogenous/allogeneic bone graft or any osteoinductive agents to treat the large bone defects caused by varies of pathogenesis and systematically study its long-term therapeutic effect and osseointegration characteristics.
Detailed description
A selection of fifty-eight patients with large bone defects caused by tumor, infection or trauma received the individualized porous implants treatment, and two typical cases were chosen for detailed study. Further, the large segmental femur defect model of sheep was utilized to study the osseointegration characteristics of the individualized porous implants in 1, 3, 6 months after implantation.
Interventions
DEVICE3D printed individualized porous implants
Use 3D printed individualized porous implants to reconstruct the large bone defects caused by tumor, infection or trauma.
Sponsors
Peking University Third Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Large bone defects (\>4cm) in spine, limb bone and hip joint caused by tumor, infection or other pathogenesis received the individualized porous implants treatment.
Exclusion criteria
* Bone defects less than 4cm long. * Bone defects treated by other methods ,such as ilizarov technique, masquelet technique or Ti mesh.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biomechanical stability | Immediate after the bone defect reconstruction. | Evaluete the immediate and long-term biomechanical stability of the bone-implant complex after surgery by the following indicator: the loosening, subsidence, displacement of the implants from radiographic examination and The symptoms of the patient. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Osseointegration | Immediate after the bone defect reconstruction. | Evaluate the osseointegration characteristics of the bone-implant complex by using CT scan to quantify the callus bridging at the outer surface of the implants or the bone growing into the porous implants. |
Countries
China
Contacts
Primary ContactTeng Zhang, PhD
Outcome results
None listed