COVID - AirPollution

Air Pollution and COVID-19 Mortality in Geriatric Patients: a Multicenter Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04463862

Enrollment

660

Registered

2020-07-09

Start date

2020-06-04

Completion date

2021-06-01

Last updated

2021-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 Confirmed Cases, COVID-19 Mortality

Keywords

Air pollution, COVID-19, Respiratory viral diseases, PM- NO2-Ozone

Brief summary

Epidemiological data have related particulate matter (PM), nitrogen dioxide (NO2) and ozone (O3) to COVID-19 morbidity and mortality at the population level. Air pollution may be related to an increase in the COVID-19 severity and lethality through its impact on chronic diseases such as cardiovascular and respiratory diseases and diabetes that are also the main comorbidities associated with COVID-19. Epidemiological studies using individual data are needed to provide more precise estimate of the association between air pollution exposure and COVID-19. In this multicenter prospective study, the investigators will analyze the number of deaths in COVID-19 confirmed cases in geriatric patients according to long-term exposure to air pollution, taking into account confounders such as diabetes, hypertension, age, and BMI. Exposure to air pollution will be estimated as the mean concentration of air pollutants at the residential address during the previous two years. In addition, the investigators will explore the relationship between short-term variations in air pollutants, relative humidity, temperature, UV radiations, pollen and the occurrence of COVID-19.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient over 60 years old (or dementia patient over 50 years old) * Patient hospitalized in a geriatric department over the period from 2020/01/01 to 2020/06/01 * Patient who underwent RT-PCR SARS-CoV-2 * Patient (or trusted person/ legal guardian/curator, if applicable) who has given consent to the re-use of his/her data (patient data) for research purposes

Exclusion criteria

None

Design outcomes

Primary

Measure	Time frame	Description
COVID-19 related-mortality	COVID-19 mortality between 2020/01/01 and 2020/06/01	Association between COVID-19 related-mortality and air pollutants concentrations estimated at the residential address of geriatric patients during the last 2 years ( from 2018/01/01 to 2019/12/31)

Secondary

Measure	Time frame	Description
COVID-19 confirmed cases	COVID-19 confirmed cases between 2020/01/01 and 2020/06/01	Association between short- term variations in air pollutants, temperature, humidity, UV, pollens and the occurrence of COVID-19 confirmed cases. Short-term variations are defined as changes in air pollutants concentrations, temperature, humidity and pollen during the 20 days preceding the hospitalization.

Countries

Belgium, France

Outcome results