Hemodynamic Instability, Liver Diseases, Liver Transplant; Complications
Conditions
Keywords
liver transplantation, mean systemic filling pressure, advanced hemodynamic monitoring, liver cirrhosis
Brief summary
Patients with end stage liver disease undergoing liver transplantation have varying degrees of intraoperative haemodynamic unstability during various phases of transplantation. It is difficult to determine the cause for hemodynamic instability in these patients and to predict the best treatments. Currently, cardiovascular resuscitation options are triggered by arterial pressure and cardiac output (CO) measures, focusing on the oxygen delivery side of the circulation. The primary determinants of cardiac output reside on the venous side. Veins are 30-50 times more compliant than arteries and contain approximately 75% of the total blood volume. Mean systemic filling pressure provides vital information on this venous side of the circulation. Mean systemic filling pressure , which is defined as the pressure equal to the pressure which would be measured if the heart should suddenly stop pumping and all (arterial and venous) the pressures in the entire circulatory system should be brought to equilibrium instantaneously, is a good, complete and reliable reflection of the total intravascular fluid compartment. We would study the Mean systemic filling pressure in liver transplant recipients and record hemodynamic, respiratory, cardiac and renal function prospectively. Follow up data for 7 days for respiratory, cardiac and renal complications will be collected, along with hospital stay, ICU stay and mortality. The association between Mean systemic filling pressure and these outcomes will be analyzed.
Interventions
None listed
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* all patients undergoing liver transplantation 18-65 years
Exclusion criteria
* pregnant patients acute liver failure, acute on chronic liver failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mean systemic filling pressures(MSFP) | 1 day | MSFP trends during liver transplantation, hourly |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| icu stay | 28 days | duration of stay in the intensive care unit |
| 28 day mortality | 28 days | mortality by all causes till day 28 |
Other
| Measure | Time frame | Description |
|---|---|---|
| respiratory complications | 7 days | number of participants needing reintubation, prolonged mechanical ventilation, intercostal drain placement |
| acute kidney injury(AKI) | 7 days | AKI incidence upto 7 days |
| cardiac complication | 7 days | number of participants with significant arrhythmias and ischemia associated with hypotension |
Countries
India
Outcome results
None listed