Role of Basal Ganglia and Thalamus in Perceptual Consciousness and Metacognition

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04461730

Acronym

METACTION

Enrollment

Registered

2020-07-08

Start date

2021-12-31

Completion date

2025-11-30

Last updated

2022-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dystonia, OCD, Parkinson Disease

Keywords

metacognition, consciousness, deep brain stimulation

Brief summary

The term perceptual awareness refers to subjective experience... or the phenomenology associated with the processing of a sensory stimulus. The term metacognition refers to our ability of introspection, knowledge and control of our own cognitive processes. The objective of this research is to establish the contribution of the basal ganglia and thalamus to the perceptual awareness and meta-cognition, using deep brain stimulation coupled with electroencephalography.

Interventions

DEVICEdeep brain stimulation

Behavioral and electroencephalographic responses will be compared on and off deep brain stimulation

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Major patient in need of brain stimulation therapy for motor disorders (Parkinson's disease, tremor, dystonia) or psychiatric disorders (OCD). * Outpatient or inpatient follow-up * Fluent in French and able to understand the study procedures * informed consent * Patient affiliated to social security * Written agreement to participate in the patient's study * Intellectual abilities compatible with the performance of cognitive or motor tasks

Exclusion criteria

* Persons referred to in Articles L1121-5 to L1121-8 of the CSP (pregnant women, parturient women, mothers, etc.) who is breastfeeding, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure * Patients in whom transient cessation of stimulation is not tolerated * Subject in period of exclusion from another study * Subject cannot be contacted in case of emergency * Subject under administrative or judicial supervision

Design outcomes

Primary

Measure	Time frame	Description
Behavioral effect of DBS on confidence	by fall 2024	Confidence in correct and incorrect responses will be compared on and off stimulation

Secondary

Measure	Time frame	Description
Effect of DBS on EEG markers of confidence	by fall 2024	EEG correlates of confidence in correct and incorrect responses will be compared on and off stimulation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026