Cardiovascular Disease
Conditions
Brief summary
Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant cardiovascular morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) is biomarker of myocardial remodeling and fibrosis; however, little is known regarding their potential association with cardiovascular events. This study aimed to investigate the release of sST2 and its association with cardiovascular events undergoing cardiac surgery.
Interventions
DIAGNOSTIC_TESTsoluble ST2
Serum sST2 was measured on a monoclonal electrochemiluminescence immunoassay. Samples were exposed to two freeze cycles before analysed. Samples were exposed to two thawfreeze cycles before analysed.
Sponsors
Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* age ≥ 18 years * Congenital heart disease requiring surgery * Valvular heart disease requiring surgery * Arrhythmia requiring surgery * Aortic dissection requiring surgery * Coronary heart disease requiring surgery
Exclusion criteria
* age \<18 years * pregnancy * severe renal dysfunction (creatinine \>200µmol/L) * not capable of understanding or signing informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 30 days after surgery | Number of participants death of 30 days after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart failure | 30 days after surgery | requiring initiation or change in heart failure medication or requiring hospitalisation |
Countries
China
Contacts
Primary ContactYong-feng Shao
Backup ContactHong Liu
Outcome results
None listed