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The Prevalence of Pulmonary Hypertension in Patients With COVID-19.

The Prevalence of Pulmonary Hypertension, With or Without Right Ventricular Loading, in Patients With COVID-19 Who Are Being Treated With a Respirator in the Intensive Care Unit.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04459364
Enrollment
67
Registered
2020-07-07
Start date
2020-06-01
Completion date
2020-07-15
Last updated
2021-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID, Hypertension, Pulmonary, Right Ventricular Overload

Brief summary

The virus infection Covid-19 fills our hospitals and intensive care departments in a very unique way and there is a lack of essential insight into the pathophysiology of the disease. As a result, very specific treatment options are missing. The US Medicines Agency (FDA) has in the last days given a general license for treatment with inhaled nitric oxide (iNO). Inhaled NO in Sweden (and Europe) is approved for the indication of pulmonary hypertension in adults. However, no one has yet described the occurrence of pulmonary hypertension, with or without right ventricular loading, in the Covid-19 patients who become so seriously ill that they need to be treated at an IVA ward. Knowledge of this is, of course, a prerequisite for determining the need for pulmonary artery catheterization (PA catheter, Swan-Ganz catheter) and also to better understand whether iNO treatment or other forms of lung selective vasodilation therapy may be of benefit to this patient group.

Detailed description

Demographics and data from study variables will be documented in paper CRFs at the investigational site. * Demography o Age, sex * Covid-19 related variables o COVID-19 diagnosis * Concomitant diseases o Comorbidity, previous and present * Cardiovascular risk factors o Smoking * Laboratory values * On-site measurements o Evaluation with echocardiography

Interventions

None listed

Sponsors

Attgeno AB
Lead SponsorINDUSTRY

Study design

Observational model
COHORT
Time perspective
OTHER

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Men and women at least 18 years of age * Diagnosed with COVID-19 and is treated at an intensive care unit.

Exclusion criteria

* Responsible investigator considers that co-morbidity is so pronounced that it does not allow reasonable interpretation of data. * Missing verified diagnosis of COVID-19

Design outcomes

Primary

MeasureTime frameDescription
PrevalenceDay 1To determine the prevalence of pulmonary hypertension and right ventricular load in patients with COVID-19 treated in intensive care unit evaluated by routine echocardiography.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026