Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome

Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome(OSA): EXODYS

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04459182

Acronym

EXODYS

Enrollment

Registered

2020-07-07

Start date

2021-01-14

Completion date

2023-07-06

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Dysfunction

Brief summary

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

Detailed description

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion. the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI \>15).

Interventions

DIAGNOSTIC_TESTENDOPAT

digital plethysmography

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adult subject * Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent * Subject with OSA (defined by AHI \>15/h)

Exclusion criteria

* cardiac or vascular desease

Design outcomes

Primary

Measure	Time frame	Description
miRNA cointained in exosomes	immediately after the consultation	compare exosome content between obese-OSA patients with endothelial dysfunction and without

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026