Myocardial Infarction
Conditions
Brief summary
The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.
Detailed description
Aberdeen scientists are at the forefront of a new type of magnetic resonance imaging (MRI), having built in-house the only two available prototypes of Fast Field-Cycling MRI in the world - and these already have clinical imaging capabilities. Fast Field-Cycling MRI switches rapidly over a range of field strengths (0.2 T to 200 µT), providing a T1 dispersion curve. This information is invisible to fixed-field scanners and uncovers unique knowledge about motion and interaction between component molecules within a tissue (i.e. water/fat/proteins). In this application the investigators wish to use their in-house expertise further to extend the capability of our Fast Field-Cycling MRI to perform cardiac imaging by building the first-ever cardiac Fast Field-Cycling MRI coil and develop cardiac pulse sequences with ECG gating. The investigators will aim to establish the normalcy of T1 dispersion curves for left ventricular myocardium in healthy volunteers, and further on to distinguish the characteristics of post-myocardial infarction scar T1 dispersion curves.
Interventions
PROCEDURECardiac Magnetic Resonance Imaging
Cardiac Magnetic Resonance Imaging - Cardiac Scan
PROCEDUREFast Field Cycling - Magnetic Resonance Imaging
Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan
PROCEDUREElectrocardiogram
Electrocardiogram
PROCEDUREEchocardiogram
Echocardiogram
Sponsors
University of Aberdeen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participant who is willing and able to give informed consent for participation in the study * Healthy volunteers willing to give informed consent for participation in the study * Patients diagnosed with a previous myocardial infarction
Exclusion criteria
* Unwillingness to participate * Claustrophobia * Contraindication to MRI scanning such as implantable cardiac devices * Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as "healthy" at the time of the study visit * Pregnancy * Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (\>50cm in diameter) * Participants with abnormal kidney function that will preclude them from receiving a contrast agent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac Magnetic Resonance Imaging | At baseline | Cardiac Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves |
| Fast Field Cycling Magnetic Resonance Imaging | At baseline | Fast Field Cycling Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves |
Countries
United Kingdom
Contacts
CONTACTJames Ross, PhD
CONTACTAmelia Rudd, MSc
PRINCIPAL_INVESTIGATORDana Dawson, DPhil
University of Aberdeen
Outcome results
None listed