Assessment of the Effects of Extensive Somatosensory Training on Pain Processing

Assessment of the Effects of Extensive Sensorimotor Training on Pain Processing

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04457466

Enrollment

100

Registered

2020-07-07

Start date

2017-10-01

Completion date

2020-07-01

Last updated

2022-03-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal Pain

Brief summary

Persistent pain may lead to several alterations in the brain activity and sensory perception (i.e. pain). Around 80% of professional musicians experience prolonged episodes of musculoskeletal pain throughout their careers, a percentage that is four times higher than in the general population. With this background, the intended experiment aims at understanding the role of several biological factors associated to sensorimotor training that can lead to alteration of the brain activity and, consequently, pain processing.

Interventions

DRUGNerve Growth Factor

Induction of experimental muscle soreness using intramuscular injections of Nerve Growth Factor.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy men and women Speak and understand English. General

Exclusion criteria

are: * Pregnancy * Drug addiction defined as the use of cannabis, opioids or other drugs * Previous neurologic or mental illnesses * Presence of a history of trauma or neurologic entrapment syndromes to the arm regions. * Lack of ability to cooperate * Frequent computer gamer ( \> 9 hours/week)

Design outcomes

Primary

Measure	Time frame	Description
Pain rating	Changes from baseline measured at day 3 and day 8	Pain on an 11-point numerical rating scale (0 = no pain, 10 = most intense pain imaginable)
Cortical Sensory Evoked Potentials	Changes from baseline measured at day 3 and day 8	Electrical stimulation will be elicited to record sensory evoked potentials using electroencephalography (EEG)
Motor Evoked Potentials	Changes from baseline measured at day 3 and day 8	Transcranial magnetic stimualtion will be used to evoke motor evoked potentials (MEPs)
Brain connectivity	Changes from baseline measured at day 3 and day 8	Continuous electroencephalography recording will be used to explore connectivity between brain areas

Secondary

Measure	Time frame	Description
Questionnaires	Changes from baseline measured at day 3 and day 8	Questionnaires about pain and muscle soreness (Pain catastrophization; State and Trait anxiety; Pain vigilance)
Pressure pain thresholds	Changes from baseline measured at day 3 and day 8	Pressure applied to the surface of the skin using a handheld algometer

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026