Proinflammatory Cytokines, Skin Conditions
Conditions
Brief summary
To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood
Interventions
DIETARY_SUPPLEMENTResveratrol drink
Subjects will consume a bottle of resveratrol drink for two months.
DIETARY_SUPPLEMENTPlacebo drink
Subjects will consume a bottle of placebo drink for two months.
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers aged above 20 years old
Exclusion criteria
* Subject who is not willing to participate in this study. * Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). * Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. * Subjects who have large spots (area \>3 square centimeter) or abnormal acne.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin moisture | 0, 4, and 8 weeks | Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120 |
| The change of skin elasticity | 0, 4, and 8 weeks | Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves |
| The change of skin wrinkles | 0, 4, and 8 weeks | VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units |
| The change of skin collagen density | 0, 4, and 8 weeks | DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score |
| The change of skin texture | 0, 4, and 8 weeks | VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units |
| The change of skin pores | 0, 4, and 8 weeks | VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units |
| The change of total antioxidant capacity of blood | 0 and 8 weeks | Total Antioxidant Capacity Assay Kit |
| The change of TNF-alpha of blood | 0 and 8 weeks | ELISA Kit |
| The change of IL-6 of blood | 0 and 8 weeks | ELISA Kit |
| The change of IL-17 of blood | 0 and 8 weeks | ELISA Kit |
| The change of IL-1β of blood | 0 and 8 weeks | ELISA Kit |
Countries
Taiwan
Outcome results
None listed