Spontaneous Abortion
Conditions
Brief summary
This study aims to determine the role of serum biomarkers and placental bloodflow in the comprehensive evaluation of the risk for spontaneous abortion
Detailed description
To study the added value (if any) of combining serum markers, immunologic factors, and ultrasound parameters in comprehensively evaluating the risk for spontaneous abortion.
Interventions
DIAGNOSTIC_TESTMarkers of ultrasound
CRL, HR, and other ultrasound measurements.
DIAGNOSTIC_TESTImmunologic factors
Measurement of NK cells subpopulations types in the maternal serum
DIAGNOSTIC_TESTSerum factors
Measuring the maternal serum concentration of sFlt-1, PLGF, glycodelin-A, and other substances.
Sponsors
Orthogyn Medical Center, Bulgaria
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* visualized fetal structures in utero & heart pulsations until 8th week of gestation * normal THS/T4 levels * no uterine malformations * BMI \< 27 * signed informed consent
Exclusion criteria
* fetal structures in utero & heart pulsations not visualized until the 8th week of gestation * elevated THS/T4 levels * uterine malformations * BMI \> 27
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of a spontaneous abortion | Up to 24 weeks of gestation | Absent heart rate pulsations on an ultrasound scan |
Countries
Bulgaria
Contacts
Primary ContactPetar N Ignatov, PhD
Outcome results
None listed